054 Blood Pressure and Mean Arterial Pressure

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Question by Adriana: How does high blood pressure speed up plaque buildup in arteries?
Could someone please explain to me how a high blood pressure flowing in arteries can speed up or make plaque build up in your arteries? This isn’t making sense to me. I thought it had more to do with lipids/cholesterol…

Best answer:

Answer by ?
You are right about the cholesterol. But don’t forget high blood pressure is like a pump pushing thru blood thicken by cholesterol harder to pus thicker the blood gets starting to stick to the walls of the arteries … Get the picture? :). —/ penny

Add your own answer in the comments!


  1. the arteries become constricted

  2. High blood pressure has nothing to do with cholesterol, although they’re caused by the same thing – dehydration. You can have either one or both at the same time.

    The common connection is when you become dehydrated, the blood thickens because the body has borrowed the water to inject into the cells.

    This thickening causes the blood to become acidic with toxins. The acidic blood is pumped through the arteries with a shearing pressure that causes tiny tears and abrasions to the inside of the artery walls. To prevent these from peeling and causing an embolism in the brain, the body produces the so-called “bad” cholesterol (aka “plaque”) to cover the damaged areas and protect them until they can be repaired.

    In high blood pressure, the water is borrowed from the blood using a process called reverse osmosis that literally squeezes the water from the arteries through tiny holes in the membrane. This squeezing pressure is reflected on the blood pressure gauge.

  3. Please don’t listen to the nutjob talking about dehydration. He doesn’t know anything about how the kidneys and blood vessels function. See more about this quackery – http://www.quackwatch.org/11Ind/batman.html

    High blood pressure causes damage to the endothelial cells that line the arteries. When endothelial cells are damaged, they release many factors that involve coagulation, inflammation, growth signals, etc. As a result of the damaged endothelium, white blood cells are more likely to adhere to the lining of the vessels, smooth muscle cells from the vessel wall are signaled to proliferate and migrate to the layer of the wall just under the surface, platelets are more likely to stick to the endothelium, etc. White blood cells and smooth muscle cells in the plaque that is developing can absorb or “eat up” oxidized LDL particules, making them into foam cells, which forms a fatty streak. The fatty streak is the first sign of atherosclerosis that you can see.

    In short, the current model of atherosclerosis is based on endothelial cell injury, which can be caused by high blood pressure. This is why hypertension is a risk factor for atherosclerosis.

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